Biodiversa srl is a start-up established in 2014 by a group of partners with a passion for scientific research, coming from different disciplines: medicine, genetics, biology, biotechnology, chemistry, physics. And this is precisely is our strength, convinced as we are that you can only overcome great challenges with an interdisciplinary approach.
Genetic analyses are, and will be more and more, essential in order to understand the state of health of people, animals and plants, to assess the viable therapies, judge the quality of food, and assess biodiversity within a certain environment. In this context, the devices of the future, in our view, will be portable, inexpensive and easy to use (so-called Point-of-Care, POC), and will be possibly used even outside laboratories, hospitals and large research centres. Their use may become critical for doctors, dentists and veterinarians, food control centres or research teams (see the Tanzania project)at work in areas uncontaminated by humans. What would be the advantages? In less than an hour, a dentist could understand the genesis of a problem, as well as a veterinarian could identify the disease that afflicts the cat or dog, and therefore, in the same session, give it the right drug (for example, a particular type of antibiotic). Finally, researchers would be able to carry out analyses in situations where it would otherwise be impossible.
The history of DNA sequencing began in 1977 with F. Sanger’s publication on the method for determining the order of nucleotides in DNA. Since that time, most applications have been based on changes and evolutions of Sanger’s algorithm. In the past ten years, however, the next-generation sequencing technologies (NGS) have made it possible to obtain short sequences with a high yield, supplanting in a short time the earlier ones. Thanks to parallel advances in various disciplines, from chemistry to bioinformatics, it is now possible to run DNA sequencing within a reasonable time and at proportionally low costs. The infrastructural costs required to run sequencers, though, and the conditions of their application still remain a strong limitation to their widespread use.